Medical Device Biocompatibility Testing Using Different Methods!
Biocompatibility is the measurement of how compatible a device or a material is within a biological system or how a device performs with a host response within an application. Biocompatibility testing is done in vitro in order to protect humans from risks that could arise from medical device materials used. This is done by measuring the acute cytotoxicity of extractable.
Biocompatibility testing may be done using Cytotoxicity testing. Cytotoxicity can be assessed using three approaches. One approach is by exposing the cells to the substances extracted after extracting the material from the device. Another approach is by placing the device material directly on the cells without damaging the cells. An indirect approach is also possible by cushioning the layer above the cells and placing the device material on that layer.
The biocompatibility of a material may be assessed by using cell culture assays or cytotoxicity testing. Cytotoxicity screens allow researchers to find more insight about potential adverse effects before cell death and are extracted through the use of in-vitro isolated cells. Cytotoxicity techniques are useful in evaluating the toxicity or irritancy potential of materials or chemicals. These are also considered an excellent way to screen materials before in vivo tests
Some other or even many compatibility tests may be required to complete the interaction assessment, especially to meet the ISO requirements.